San Francisco 49ers at Los Angeles Rams Betting Preview

Sunday, November 29, 2020, SoFi Stadium, Inglewood, California, 4:05 p.m. ET

49ers at Rams Betting Preview: 49ers (+6.5/-120), Rams (-6.5/-102)

San Francisco 49ers

Jimmy Garoppolo threw for three touchdown passes when the 49ers defeated the Rams at home on Oct. 12, but he is on injured reserve now with an ankle injury. Not only that, but the TD receptions came from George Kittle (foot), Deebo Samuel (hamstring) and Brandon Aiyuk (trying to return from the COVID-19 list).

The 49ers have lost three consecutive games behind quarterback Nick Mullens and not only does a return to the Super Bowl look out of the question, San Francisco might not make the playoffs at 4-6. Running back Raheem Mostert (ankle) and cornerback Richard Sherman (calf) could be ready to play Sunday. Sherman has not seen action since the season opener.

Los Angeles Rams

Questions about whether or not the Rams could defeat anybody of significance were answered in consecutive weeks when they topped the Seahawks on Nov. 15 and took care of the Buccaneers on the road Monday night.

Head coach Sean McVay is known for his offensive innovation, but the Rams have forged a 7-3 record behind a defense that entered Week 12 No. 1 in the NFL by allowing 291.9 yards per game. Rams All-Pro defensive tackle Aaron Donald doesn’t have a sack or a tackle in the last two weeks but that isn’t motivating him this week. He said he heard some chatter from the 49ers the last time the teams played and intends to “show ’em how we play.”

49ers at Rams Betting Pick for Week 12

The 49ers defeated the Rams earlier this season thanks to a big first half when Garoppolo made quick throws to diffuse the aggressive L.A. pass rush. The Rams made second-half adjustments but couldn’t get their offense going in a messy 24-16 defeat.

The Rams are even better on both sides of the ball than they were a month ago and are playing at home Sunday where they are 4-0.

49ers at Rams Betting Pick: Rams 38, 49ers 17

49ers at Rams Best Bet for Week 12

The Rams still have not delivered a breakout game offensively, unless their 35-32 defeat at Buffalo counts in Week 3. They leaned on the pass in defeating the Buccaneers on Monday and have been solid in the running game all season so they have multiple options to stay in a flow.

Donald already has said he is motivated to do damage on defense against the 49ers this week and as he goes so does his team. The Rams figure to be relentless, leaving the 49ers to play catch up.

49ers at Rams Best Bet: OVER 53.5 total points (-110)