Best Against the Spread Picks for Week 1

By: James Tillman 

James Tillman’s NFL Best Bets for Week 1

Are you ready for some football? Those are the six words that mean that the upcoming football season is right around the corner. For obvious reasons, this is big-time news for NFL fans. The big game that took place back in February saw the Kansas City Chiefs take on the San Francisco 49ers. San Francisco led by a double-digit margin in the final frame.  

But as they had done several times before, the Chiefs managed to overcome that advantage en route to winning the team’s first Super Bowl title in five decades. Was this win the beginning of the next NFL dynasty, or will someone challenge the champions during the 2020 NFL season? But before we start getting too far ahead of ourselves here, let’s take a look at our best pick(s) for Week 1. 

NFL Best Bet ATS for Week 1, No. 1: Arizona Cardinals at San Francisco 49ers

San Francisco 49ers (-7) vs. Arizona Cardinals 

For our first sure pick, we have a matchup between two division rivals. Last season, the 49ers finished with one of the best records in the league at 13-3. Additionally, the 49ers had the fourth-best offense in the NFL, totaling 381.1 yards per game and they also had the second-best defense in the league as well, giving up just 281.8 yards per outing.  

Meanwhile, the Cardinals finished last in the NFC West at 5-10. Along with that, the Cardinals had the 21st-best offense in the NFL and finished dead last in total yards allowed per game at 402. Based on the numbers, the 49ers should not only win this game, but they should also cover the spread as well.  

NFL Best Bet ATS for Week 1, No. 2: Houston Texans at Kansas City Chiefs

Houston Texans vs. Kansas City Chiefs (-9) 

Ironically, these two teams faced off in last year’s AFC divisional playoffs. In that contest, the Houston Texans were rolling early as they jumped out to a 24-0 lead. Unfortunately for the Texans, that three-score lead would not hold up. In fact, the Chiefs erased the huge deficit thanks to scoring 41 consecutive points.  

And when it was all said and done, the Chiefs ended up winning the game by a 51-31 margin. It was the biggest comeback win in franchise history. While the Texans should prove to be a formidable opponent for the defending champs, look for the Chiefs to get the better of their opponent this time around as well and start the season off on a high note and win by double-digits.