Buffalo Bills at San Francisco 49ers Betting Preview

Bills vs. 49ers Betting Preview: Bills (-1/-107), 49ers (+1/-113)

Buffalo Bills

The Bills (8-3) retained their one-game lead in the AFC East with a 27-17 victory over the Los Angeles Chargers last week in a game that featured a 20-yard touchdown pass from Cole Beasley to fellow wideout Gabriel Davis. Quarterback Josh Allen also had a TD pass and a 3-yard scoring run in the win.

The Bills overcame a season-high-tying three turnovers in the triumph. It was just the third time this season that they’ve had more turnovers than their opponent, and the result made them 2-1 in those games.

Monday’s game against the 49ers matches a Buffalo team that rates below average in all three major defensive categories (rushing, passing and total) against a San Francisco team that’s above average in all three defensive categories. The Bills have been outgained in six of their past nine games, although they have found a way to win six of those contests.

San Francisco 49ers

The 49ers (5-6) will face the Buffalo Bills in a neutral-site game Monday in Glendale, Ariz., but will hold an advantage both in familiarity and in recent results at the home of the Arizona Cardinals. The 49ers spent the week practicing in Arizona and even got an opportunity to work out at the stadium. They won 28-25 over the Cardinals in their last visit in 2019, though the Bills were there more recently, having lost 32-20 at Arizona last month.

The 49ers got back two key offensive weapons in last week’s 23-20 road win over the Los Angeles Rams. Wideout Deebo Samuel made an explosive return from a hamstring injury with 11 catches for 133 yards while top back Raheem Mostert had a team-high 43 rushing yards and a touchdown in his comeback from an ankle injury.

Due in part to the returns of cornerback Richard Sherman and safety Jimmie Ward from injuries, the 49ers have made steady improvement on defense, allowing (in order) 37, 34, 27 and 20 points in their past four games.

Bills vs. 49ers Betting Pick for Week 3

In a duel between first- and last-place teams, making the case for the latter is easier than you might think. And this is despite the fact that the last-place team won’t be able to play the game at home as originally scheduled.

The 49ers played arguably their best game of the season last week against the Rams, getting strong efforts from offensive and defensive units that are getting healthier. The Bills, meanwhile, are without one of their key offensive weapons — wideout John Brown (ankle) — and they don’t have many to start with.

Bills vs. 49ers Betting Pick: 49ers 27, Bills 16

Bills vs. 49ers Best Bet for Week 13

If you’re looking for the weak link in an 8-3 club, it’s a rushing defense that ranks 25th in the NFL. The 49ers rank just 16th in running the ball, but they returned two of their top backs last week (Mostert and Jeff Wilson Jr.) and looked more like the team that led the NFC in rushing a year ago. Nobody likes milking a clock more than San Francisco coach Kyle Shanahan.

Bills vs. 49ers Best Bet: UNDER 48 total points (-110)