Sunday, November 15, 2020, Mercedes Benz Superdome, New Orleans, 4:25 p.m. ET
49ers at Saints Betting Preview: Saints (-9/-430), 49ers (+9/+330)
San Francisco 49ers
Quarterback Nick Mullens has put up 250-plus passing yards in eight of his 11 career starts and the 49ers know what it’s like to be in a shootout in this building. They beat the Saints 48-46 in New Orleans last season but their roster looks a bit different for this Sunday afternoon showcase.
Some of the usual names are set to take the field, and Raheem Mostert could key the entire plan from Kyle Shanahan. Mostert had 109 total yards and two scores in last year’s meeting.
But the 49ers will need help from their unheralded supporting cast to keep this one close.
One such candidate is Richie James, who had nine catches for 184 yards and his third career touchdown in Week 9. James is likely to garner the full attention of the Saints’ veteran secondary.
Defense has been the downfall of the 49ers on the road and personnel continues to be a concern. No Nick Bosa and constant injuries in the secondary has set up opposing quarterbacks to feast on San Francisco’s pass defense. Saints quarterback Drew Brees has three TD passes in three straight games against the Niners.
New Orleans Saints
Brees looked like his vintage self in Week 9 with a season-high four TD passes and the zip on his passes of 30-something Drew. Like San Francisco, the Saints key their plan around running back Alvin Kamara, who is in Priest Holmes-Marshall Faulk territory in terms of total production through eight games and the main reason New Orleans is standing up a 6-2 record.
Kamara tops the NFL with 1,036 total yards — 565 receiving, 471 rushing — and would be the first player in NFL history with 500-plus rushing yards and 500-plus receiving yards in each of his first four seasons in NFL history.
There could be a big boon for Brees and the passing game with Michael Thomas looking healthy. Thomas had 11 receptions for 134 yards against the Niners last season.
49ers at Saints Betting Pick for Week 10
Brees is rolling and the Saints are showing some teeth defensively, while the Niners are showing the wear and tear of a “Super Bowl schedule” that includes a rugged NFC West slate.
Expect New Orleans to come out firing and San Francisco to keep it tight for a half before losing steam.
49ers at Saints Betting Pick:
Saints 33, 49ers 24
49ers at Saints Best Bet for Week 10
Kamara and Thomas get the deserved attention but the 49ers have been unable to contain top tight ends. In last year’s game, Cook hauled in two touchdowns and narrowly missed on another big gainer.
49ers at Saints Best Bet: Saints TE Jared Cook anytime TD (+200)