Sunday, November 15, 2020, State Farm Stadium, Glendale, Ariz., 4:05 p.m. ET
Bills at Cardinals Betting Preview: Bills (+2/+114), Cardinals (-2/-134)
The Bills (7-2) will go for their fourth win in a row when they visit the desert to take on the Cardinals this weekend. Buffalo already has one four-game winning streak this season, as it opened the 2020 campaign at 4-0 before dropping back-to-back contests.
Buffalo is 3-1 on the road this season, including a win at Las Vegas, so a long road trip is not necessarily as detrimental as some might assume. Josh Allen’s performance will be much more important than a long plane ride, and the quarterback is coming off one of his best performances of the season in a 44-34 win over the Seattle Seahawks last week. He threw for 415 yards and three touchdowns while completing 31 of 38 passes.
Defense could be more of a question mark. The Bills gave up 34 points last week after allowing only 31 points combined in their previous two games.
The Cardinals (5-3) sure love to play thrilling games, and this week might be no different as they host the Bills. Arizona is looking to bounce back from a 34-31 loss against the Dolphins last week, which followed a three-point win over the Seahawks in overtime one week earlier. Put the scores together, and Arizona is even at 68-apiece against its opponents in the last two weeks.
The Cardinals come in hot on offense, having scored 30-plus points in each of their past four games. Kyler Murray has tossed at least one touchdown pass in every game this season, and he has five games with multiple passing TDs.
As with Buffalo, Arizona is less consistent on defense. The Cardinals have given up 30-plus points in back-to-back games and three times overall this season.
Bills at Cardinals Betting Pick for Week 10
Arizona is getting a lot of hype because of Murray and the team’s high-flying offense, but Buffalo is at least as dangerous. Allen & Co. have proved that they can travel west and win, and the Bills’ defense is capable of sniffing out takeaways.
In a highly entertaining and hard-fought matchup, look for the Bills to find a way to outlast their hosts. Allen and Murray will provide plenty of highlights with their arms as well as their feet.
Bills at Cardinals Betting Pick:
Bills 34, Cardinals 31
Bills at Cardinals Best Bet for Week 10
One could make the argument that the Bills and Cardinals are due for a quieter game on offense after stringing together some high-scoring weeks. But the guess here is that another shootout could be in store between two talented and hungry teams eager to bolster their playoff chances.
Bills at Cardinals Best Bet: OVER 56 total points (-118)